Description
The name causes confusion, so it is worth being precise: this vial contains CJC-1295 without the drug affinity complex, also called Modified GRF(1-29). It is not the long-acting DAC conjugate.
Mod GRF 1-29: four substitutions, one purpose
The molecule starts from GRF(1-29) amide, the shortest fully active fragment of growth-hormone-releasing hormone, and swaps four residues: D-alanine at position 2, glutamine at 8, alanine at 15 and leucine at 27. The first substitution blocks cleavage by dipeptidyl peptidase-4, and the others reduce rearrangement and oxidation, giving a sequence that survives longer in assay media than native GRF(1-29).
In research it is used to study the GHRH receptor, typically through cAMP accumulation in receptor-expressing cells or in pituitary cell preparations. It is often run beside a ghrelin-receptor agonist such as ipamorelin, since the two act on different receptors; we also stock that pairing as a 10 mg blend.
Compound identity and specification
| Compound | CJC-1295 without DAC (Mod GRF 1-29) |
|---|---|
| Sequence | [D-Ala2, Gln8, Ala15, Leu27]-GRF(1-29) amide |
| Molecular formula | C152H252N44O42 |
| Molecular mass | 3367.9 g/mol |
| CAS registry number | 863288-34-0 |
| PubChem | CID 56841945 |
| Vial content | 5 mg |
| Physical form | Lyophilised powder in a sealed vial |
| Analysis | Third-party HPLC and purity testing to a 99%+ specification; certificates are posted on our COAs page |
| Supplied for | Laboratory research use only |
Questions about CJC-1295 Peptide (No DAC) 5mg
What does ‘No DAC’ mean?
DAC stands for drug affinity complex, a lysine-linked reactive group added to some versions. This product has no DAC and is the Mod GRF(1-29) peptide.
How does this differ from sermorelin?
Sermorelin is native GRF(1-29) amide. CJC-1295 without DAC carries four substitutions that make it more resistant to enzymatic breakdown.
What molecular mass should I expect?
3367.9 g/mol for the C152H252N44O42 peptide, as listed in the identity table below.
Research literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Jette L, et al. Endocrinology. 2005;146(7):3052-3058. In cultured rat anterior pituitary cells and Sprague-Dawley rats, measured GH secretion, Cys34-albumin conjugate formation and resistance to DPP-IV cleavage. Source · PMID 15817669
- Alba M, et al. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. In GHRH-knockout mice, measured pituitary GH and IGF-I expression. Source · PMID 16822960
Certificates for our compounds are posted on the certificates of analysis page and matched to vials by cap and crimp colour. If the one for this product is not up yet, contact the order desk.
Related research compounds
Browse more compounds in GHS, or view the full research peptide catalogue.
Supplied for laboratory research use only. Not for human or veterinary use.
