Description
Ipamorelin is small, synthetic and built largely from non-standard residues. Those choices are what give it its reputation for selectivity at the ghrelin receptor.
Ipamorelin 5 mg, a selective GHS-R1a agonist
Its five residues include aminoisobutyric acid, D-2-naphthylalanine and D-phenylalanine, none of which occur in ordinary proteins. They make the peptide resistant to many proteases and shape it to fit the growth hormone secretagogue receptor. In the original characterisation, ipamorelin stimulated growth hormone release in animal models without the rise in ACTH or cortisol seen with earlier secretagogues, and that selectivity is still the reason it is chosen as a receptor tool.
The 5 mg vial covers receptor-binding and signalling assays at typical working concentrations with room to spare. For labs pairing it with a GHRH-receptor agonist, the CJC-1295 blend is also available.
Compound identity and specification
| Compound | Ipamorelin |
|---|---|
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Molecular formula | C38H49N9O5 |
| Molecular mass | 711.9 g/mol |
| CAS registry number | 170851-70-4 |
| PubChem | CID 9831659 |
| Vial content | 5 mg |
| Physical form | Lyophilised powder in a sealed vial |
| Analysis | Third-party HPLC and purity testing to a 99%+ specification; certificates are posted on our COAs page |
| Supplied for | Laboratory research use only |
Questions about Ipamorelin 5mg
What receptor does ipamorelin act on?
The growth hormone secretagogue receptor, GHS-R1a, which is also the receptor for ghrelin.
Why is the sequence written with Aib and D-2-Nal?
Those are non-proteinogenic residues: aminoisobutyric acid and the D-isomer of 2-naphthylalanine. They are part of the defined structure, not impurities.
Is there a larger vial?
Yes, ipamorelin is also stocked at 10 mg, which lowers the cost per milligram.
Research literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Raun K, et al. Eur J Endocrinol. 1998;139(5):552-561. In primary rat pituitary cell culture, anaesthetised rats and conscious swine, measured GH release and the absence of concomitant ACTH and cortisol elevation. Source · PMID 9849822
- Johansen PB, et al. Growth Horm IGF Res. 1999;9(2):106-113. In rats, measured longitudinal bone growth following administration. Source · PMID 10373343
- Svensson J, et al. J Endocrinol. 2000;165(3):569-577. In adult female rats, characterised the response to chronic secretagogue exposure; see the linked record for endpoints. Source · PMID 10828840
Certificates for our compounds are posted on the certificates of analysis page and matched to vials by cap and crimp colour. If the one for this product is not up yet, contact the order desk.
Related research compounds
Browse more compounds in GHS, or view the full research peptide catalogue.
Supplied for laboratory research use only. Not for human or veterinary use.
