Description
Epitalon, also spelled epithalon, is about as small as a research peptide gets: four residues and a mass of 390.35 g/mol.
Epitalon 10 mg, a four-residue synthetic peptide
The sequence Ala-Glu-Asp-Gly was designed as a synthetic counterpart to an extract of the pineal gland studied in Russia from the 1980s onward. With two acidic residues out of four it is strongly negatively charged, very water-soluble and elutes early on reversed-phase HPLC, which means purity methods often use a shallow gradient near the start of the run.
Most of the literature comes from cell culture and animal models, notably work on telomerase activity in cultured cells. Much of it originates from a small number of research groups, and independent replication is limited, which is worth weighing when designing studies around it.
Compound identity and specification
| Compound | Epitalon (also written Epithalon) |
|---|---|
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Molecular formula | C14H22N4O9 |
| Molecular mass | 390.35 g/mol |
| CAS registry number | 307297-39-8 |
| PubChem | CID 219042 |
| Vial content | 10 mg |
| Physical form | Lyophilised powder in a sealed vial |
| Analysis | Third-party HPLC and purity testing to a 99%+ specification; certificates are posted on our COAs page |
| Supplied for | Laboratory research use only |
Questions about Epitalon 10mg
Is it Epitalon or Epithalon?
Both spellings refer to the same AEDG tetrapeptide.
Why does epitalon elute so early on HPLC?
It is short and highly polar, so it interacts only weakly with a C18 column.
What strength is available?
10 mg per vial, with quantity breaks from two vials.
Research literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Khavinson VKh, et al. Bull Exp Biol Med. 2003;135(6):590-592. In cultures of telomerase-negative human fetal fibroblasts, measured telomerase catalytic subunit expression, enzymatic activity and telomere length. Source · PMID 12937682
- Anisimov VN, et al. Biogerontology. 2003;4(4):193-202. In female SHR mice, measured bone-marrow chromosome aberration frequency; see the linked record for the full endpoint set. Source · PMID 14501183
- Al-Dulaimi S, et al. Biogerontology. 2025;26:178. In normal human fibroblasts, HMEC epithelial cells and immortalised epithelial lines, measured telomere length, hTERT mRNA, telomerase activity and ALT markers. Source · PMID 40908429
Literature notes: Most published work originates from a single research group with limited independent replication. A correction to the 2025 paper was published in November 2025; consult the version of record.
Certificates for our compounds are posted on the certificates of analysis page and matched to vials by cap and crimp colour. If the one for this product is not up yet, contact the order desk.
Related research compounds
Browse more compounds in Mitochondrial & Cellular Compounds, or view the full research peptide catalogue.
Supplied for laboratory research use only. Not for human or veterinary use.
