Description
SS-31 belongs to the Szeto-Schiller family of short peptides designed to cross cell membranes and concentrate in the inner mitochondrial membrane.
SS-31 10 mg, a cardiolipin-targeting tetrapeptide
Its four residues alternate aromatic and basic side chains: D-arginine, 2,6-dimethyltyrosine (Dmt), lysine and phenylalanine amide. That pattern gives a net charge of +3 at physiological pH while staying small enough, at 639.8 g/mol, to pass through membranes. Research attention focuses on its association with cardiolipin, a phospholipid found almost only in the inner mitochondrial membrane.
Labs use it in isolated-mitochondria and cell-culture models of oxidative stress and membrane organisation. The non-standard Dmt residue means it should be characterised against its own reference data rather than by analogy with ordinary tetrapeptides.
Compound identity and specification
| Compound | SS-31 (elamipretide) |
|---|---|
| Sequence | D-Arg-Dmt-Lys-Phe-NH2 |
| Molecular formula | C32H49N9O5 |
| Molecular mass | 639.8 g/mol |
| CAS registry number | 736992-21-5 |
| PubChem | CID 11764719 |
| Vial content | 10 mg |
| Physical form | Lyophilised powder in a sealed vial |
| Analysis | Third-party HPLC and purity testing to a 99%+ specification; certificates are posted on our COAs page |
| Supplied for | Laboratory research use only |
Questions about SS-31 Peptide 10mg
What is Dmt?
2,6-dimethyltyrosine, a modified tyrosine that is part of the designed SS-31 sequence.
Why is SS-31 described as cell-permeable?
Its alternating aromatic and cationic residues let it cross membranes despite carrying a positive charge.
What is SS-31 also known as?
Elamipretide. Both names describe the same D-Arg-Dmt-Lys-Phe-NH2 peptide.
Research literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Zhao K, et al. J Biol Chem. 2004;279(33):34682-34690. In neuronal cells and isolated mitochondria, measured intracellular ROS, mitochondrial swelling and membrane depolarisation at nanomolar concentrations. Source · PMID 15178689
- Birk AV, et al. J Am Soc Nephrol. 2013;24(8):1250-1261. In ischaemic rat kidney, measured high-affinity cardiolipin binding, inhibition of cytochrome c peroxidase activity and cristae ultrastructure. Source · PMID 23813215
- Mitchell W, et al. J Biol Chem. 2020;295(21):7452-7469. In model membranes and isolated mitochondria, measured interfacial partitioning as a function of bilayer surface charge, lipid packing and surface electrostatics. Source · PMID 32273339
Certificates for our compounds are posted on the certificates of analysis page and matched to vials by cap and crimp colour. If the one for this product is not up yet, contact the order desk.
Related research compounds
Browse more compounds in Mitochondrial & Cellular Compounds, or view the full research peptide catalogue.
Supplied for laboratory research use only. Not for human or veterinary use.
