Description
Semax takes four residues from adrenocorticotropic hormone and adds a Pro-Gly-Pro tail. The tail is there to slow enzymatic breakdown, and it is the part most analytical questions come back to.
Semax 10 mg, an extended ACTH fragment
The sequence MEHFPGP carries the ACTH(4-7) stretch Met-Glu-His-Phe, which has no hormonal activity at the adrenal gland on its own, followed by the tripeptide Pro-Gly-Pro. Its molecular mass is 813.9 g/mol. The N-terminal methionine oxidises to the sulfoxide under air and light, so a small early peak on HPLC is a known degradation marker rather than a mystery impurity.
Published work is concentrated in rodent neuroscience models and in studies of neurotrophic factor expression in cultured cells. The 10 mg vial is sized for those cell-based and analytical studies.
Compound identity and specification
| Compound | Semax |
|---|---|
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) |
| Molecular formula | C37H51N9O10S |
| Molecular mass | 813.9 g/mol |
| CAS registry number | 80714-61-0 |
| PubChem | CID 9811102 |
| Vial content | 10 mg |
| Physical form | Lyophilised powder in a sealed vial |
| Analysis | Third-party HPLC and purity testing to a 99%+ specification; certificates are posted on our COAs page |
| Supplied for | Laboratory research use only |
Questions about Semax 10mg
What does the Pro-Gly-Pro tail do?
It makes the peptide more resistant to peptidases than the bare ACTH(4-7) fragment.
How do I limit methionine oxidation?
Keep the powder frozen, dry and dark, and prepare solutions shortly before use.
Is Semax related to Selank?
Both end in Pro-Gly-Pro, but they are built on different parent sequences: ACTH for Semax, tuftsin for Selank.
Research literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Dolotov OV, et al. Brain Res. 2006;1117(1):54-60. In rat hippocampus, measured BDNF and trkB mRNA and protein expression following administration. Source · PMID 16996037
- Shadrina MI, et al. Neurosci Lett. 2001;308(2):115-118. In primary rat glial cell culture, measured rapid induction of BDNF and NGF mRNA. Source · PMID 11457573
- Sudarkina OY, et al. Int J Mol Sci. 2021;22(12):6179. In rat brain after transient middle cerebral artery occlusion, measured CREB activation and MMP-9, c-Fos and JNK protein levels. Source · PMID 34201112
Certificates for our compounds are posted on the certificates of analysis page and matched to vials by cap and crimp colour. If the one for this product is not up yet, contact the order desk.
Related research compounds
Browse more compounds in Neuropeptides, or view the full research peptide catalogue.
Supplied for laboratory research use only. Not for human or veterinary use.
