Description
Delta sleep-inducing peptide was isolated in 1977 from the venous blood of rabbits. Decades later its precise physiological role is still debated, which is part of why it remains a research subject.
DSIP 5 mg, a nine-residue neuropeptide
The sequence WAGGDASGE has a mass of 848.8 g/mol and carries a single tryptophan at the N-terminus, which gives it a useful UV absorbance at 280 nm alongside the peptide-bond signal at 214 nm. Three glycines make the chain flexible and the two acidic residues give it a net negative charge.
It has been studied in animal models and in brain-tissue preparations, including work on its effects on hormone release. As with several older neuropeptides, results vary between groups, so careful controls matter more than usual.
Compound identity and specification
| Compound | DSIP |
|---|---|
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) |
| Molecular formula | C35H48N10O15 |
| Molecular mass | 848.8 g/mol |
| CAS registry number | 62568-57-4 |
| PubChem | CID 68816 |
| Vial content | 5 mg |
| Physical form | Lyophilised powder in a sealed vial |
| Analysis | Third-party HPLC and purity testing to a 99%+ specification; certificates are posted on our COAs page |
| Supplied for | Laboratory research use only |
Questions about DSIP Peptide 5mg
Why detect DSIP at 280 nm as well as 214 nm?
Its tryptophan absorbs at 280 nm, which gives a second, more selective wavelength for checking identity.
Is DSIP chemically stable?
It has no cysteine or methionine, but tryptophan can oxidise under light. Store it dark and dry.
What does DSIP stand for?
Delta sleep-inducing peptide, a name taken from the original 1977 report.
Research literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Nakamura A, et al. J Neurochem. 1991;57(3):1013-1018. In rat medullary and regional brain synaptosomes, measured calcium-dependent, tetrodotoxin-insensitive Met-enkephalin release and calcium uptake. Source · PMID 1861139
- Nakamura A, et al. Neuropeptides. 1993;24(3):131-138. In rat brain synaptosome preparations, measured depolarisation-evoked release and aminopeptidase-mediated degradation. Source · PMID 8474631
- Iyer KS, McCann SM Neuroendocrinology. 46(1):93-95. In rat median eminence tissue in vitro, measured concentration-dependent inhibition of somatostatin release, blocked by the dopamine antagonist pimozide. Source · PMID 2886936
Literature notes: The publication year for Iyer and McCann is recorded inconsistently across indexes; the identifiers are confirmed.
Certificates for our compounds are posted on the certificates of analysis page and matched to vials by cap and crimp colour. If the one for this product is not up yet, contact the order desk.
Related research compounds
Browse more compounds in Neuropeptides, or view the full research peptide catalogue.
Supplied for laboratory research use only. Not for human or veterinary use.
