Description
This vial is a research-grade agonist of the glucagon-like peptide-1 receptor, one of the most studied class B G-protein-coupled receptors. It is sold for bench work on that receptor and nothing else.
GLP-1 10 mg for receptor pharmacology
The GLP-1 receptor couples mainly to Gs, so agonist binding raises intracellular cAMP. That makes cAMP accumulation, measured by HTRF, luminescence or reporter-gene assays, the standard functional readout, with receptor internalisation and beta-arrestin recruitment as common secondary measures. A well-characterised agonist is the reference point every one of those assays needs.
Class B receptors bind their peptide ligands in two steps, first through a large extracellular domain and then within the transmembrane core. Differences in how agonists engage those two sites are behind much of the current work on biased signalling at this receptor, and a consistent supply of agonist is what lets those comparisons hold across months of experiments.
Receptor profile and specification
| Compound class | GLP-1 receptor agonist peptide |
|---|---|
| Target receptors | GLP-1R (class B GPCR) |
| Primary functional readout | Gs-coupled cAMP accumulation in receptor-expressing cells |
| Vial content | 10 mg |
| Physical form | Lyophilised powder in a sealed vial |
| Analysis | Third-party HPLC and purity testing to a 99%+ specification; certificates are posted on our COAs page |
| Supplied for | Laboratory research use only |
Questions about GLP-1 Peptide 10mg
What is the main functional readout for GLP-1 receptor agonists?
cAMP accumulation in cells expressing the receptor, since the receptor couples primarily to Gs.
How is this vial supplied?
As 10 mg of lyophilised peptide in a sealed vial, labelled with the compound and strength.
Are larger strengths available?
Yes, 15 mg and 20 mg, which lower the cost per milligram.
Certificates for our compounds are posted on the certificates of analysis page and matched to vials by cap and crimp colour. If the one for this product is not up yet, contact the order desk.
Related research compounds
Browse more compounds in Incretin & Glucagon Peptides, or view the full research peptide catalogue.
Supplied for laboratory research use only. Not for human or veterinary use.
