Description
KLOW is the four-component version of GLOW. The extra K stands for KPV, the Lys-Pro-Val tripeptide from the C-terminus of alpha-MSH.
KLOW 80 mg: GLOW plus KPV
Each vial contains 10 mg of BPC-157, 10 mg of TB-500, 50 mg of GHK-Cu and 10 mg of KPV. KPV is the smallest component at 342.43 g/mol and, like GHK-Cu, elutes early on reversed-phase HPLC, so methods need enough resolution at the start of the gradient to separate the two tripeptides.
Four components mean four entries in the identity table and four peaks to account for. For studies where any one ratio needs to vary, the single-compound vials are the better tool; KLOW serves labs that have fixed on this combination.
Compound identity and specification
| Component | Sequence | Formula | Mass (g/mol) | CAS |
|---|---|---|---|---|
| BPC-157 CID 9941957 | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV) | C62H98N16O22 | 1419.5 | 137525-51-0 |
| TB-500 CID 62707662 | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (acetylated LKKTETQ, the thymosin beta-4 17-23 region) | C38H68N10O14 | 889.0 | 885340-08-9 |
| GHK-Cu CID 73587 | Gly-His-Lys, supplied as the copper(II) complex | C14H24N6O4 (free tripeptide); C14H23CuN6O4 as the copper complex | 340.38 free tripeptide; 402.92 as the copper complex | 49557-75-7 (GHK); 89030-95-5 (copper tripeptide-1) |
| KPV CID 125672 | Lys-Pro-Val | C16H30N4O4 | 342.43 | 67727-97-3 |
Questions about KLOW Peptide Blend 80mg
What does KPV add?
A third short peptide, Lys-Pro-Val, derived from the end of alpha-MSH.
How many peaks should a KLOW chromatogram show?
Four main peaks, one per component.
Is KPV sold separately?
Not at present. It is available as part of the KLOW blend.
Research literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Chang CH, et al. J Appl Physiol. 2011;110(3):774-780. In rat Achilles tendon explant culture and isolated tendon fibroblasts, measured explant outgrowth, fibroblast survival under oxidative stress, migration, and FAK/paxillin phosphorylation. Source · PMID 21030672
- Hsieh MJ, et al. J Mol Med (Berl). 2017;95(3):323-333. In chick chorioallantoic membrane assay, a rat hind-limb ischaemia model and human endothelial cell culture, measured vessel density, endothelial tube formation and VEGFR2-Akt-eNOS phosphorylation. Source · PMID 27847966
- Chang CH, et al. Molecules. 2014;19(11):19066-19077. In primary tendon fibroblasts from Sprague-Dawley rat Achilles tendon, measured growth hormone receptor mRNA and protein levels, PCNA expression and JAK2 phosphorylation. Source · PMID 25415472
- Bock-Marquette I, et al. Nature. 2004;432(7016):466-472. In embryonic mouse cardiomyocyte and endothelial culture and a mouse coronary artery ligation model, measured cell migration, myocyte survival and ILK/Akt kinase activity. Source · PMID 15565145
- Malinda KM, et al. FASEB J. 1997;11(6):474-481. In human umbilical vein endothelial cell (HUVEC) culture, measured directional chemotactic migration in Boyden-chamber assays. Source · PMID 9194528
- Philp D, et al. FASEB J. 2003;17(14):2103-2105. In HUVEC culture and chick aortic arch explants, measured migration, adhesion and vessel sprouting elicited by the LKKTETQ actin-binding motif at approximately 50 nM. Source · PMID 14500546
- Maquart FX, et al. FEBS Lett. 1988;238(2):343-346. In cultured fibroblasts, measured collagen synthesis rates in response to the GHK-Cu2+ complex. Source · PMID 3169264
- Simeon A, et al. Life Sci. 2000;67(18):2257-2265. In fibroblast culture, measured matrix metalloproteinase-2 expression and activity by zymography after GHK-Cu2+ exposure. Source · PMID 11045606
- Simeon A, et al. J Invest Dermatol. 2000;115(6):962-968. In rat dermal fibroblast culture and a rodent in vivo model, measured glycosaminoglycan levels and decorin and biglycan mRNA. Source · PMID 11121126
- Dalmasso G, et al. Gastroenterology. 2008;134(1):166-178. In Caco2-BBE and HT29-Cl.19A intestinal epithelial cells and murine colitis models, measured PepT1-mediated uptake kinetics, NF-kB activation and cytokine secretion. Source · PMID 18061177
- Cutuli M, et al. J Leukoc Biol. 2000;67(2):233-239. In broth and agar antimicrobial assays against Staphylococcus aureus and Candida albicans, measured colony-forming unit inhibition and microbial cAMP changes. Source · PMID 10670585
Literature notes: The published base for this compound is small and concentrated in a limited number of research groups, with little independent replication of in vivo findings. Published work concerns full-length thymosin beta-4 or its LKKTETQ actin-binding fragment. Equivalence between those and material marketed as TB-500 is not established in the literature. The published base is narrow and concentrated in gastrointestinal inflammation models.
Certificates for our compounds are posted on the certificates of analysis page and matched to vials by cap and crimp colour. If the one for this product is not up yet, contact the order desk.
Related research compounds
Browse more compounds in Multi-Peptide Blends, or view the full research peptide catalogue.
Supplied for laboratory research use only. Not for human or veterinary use.
